Book now at the Comfort Inn & Suites hotel in Hannibal, MO. This 100% smoke-free hotel is located near Rockcliffe Mansion, Mark Twain Riverboat, Mark Twain Museum, Cameron Cave, and Hannibal Downtown Trolley. Amenities include free hot breakfast, free WiFi, an indoor heated pool, a fitness center, and guest laundry facilities. All guest rooms feature sofa beds, microwaves, refrigerators, and AC and USB recharge devices. Whether traveling to Hannibal, MO for business or leisure, the Comfort Inn & Suites has everything you need. Book today!