Welcome to the Holiday Inn Express Florence Hotel. This premiere Holiday Inn Express hotel is conveniently situated on Hwy 327 and I 95 in Florence SC. Our hotels location in the suburbs takes you away from the citys hustle and bustle while keeping you close to important sites like Florence Regional Airport. When you are looking for convenient business hotels in Florence the Holiday Inn Express hotel is a perfect choice. We are surrounded by companies including Angus Palm Beneteau Blanchard Machinery DuPont FedEx HJ Heinz Honda IFH Johnson Controls Monster NuCor Steel Pepsi Roche Carolina Smurfit Stone and QVC. We are also just minutes from Francis Marion University. Leisure guests love the convenience of our hotels Florence locale. Close to numerous local highlights including the Country Club of SC Darlington Raceway and Freedom Florence we are ideal for traveling families. Whether business or pleasure brings you to Florence SC our hotels choice amenities satisfy your needs. Connect to friends or family with our free Internet access enjoy our fitness center browse through our convenient sundry shop and relax in our heated indoor pool. You will have a great start to each day with our Express Start Breakfast bar featuring hot items signature cinnamon rolls and coffee. Stay Smart with us.