The Comfort Inn PA Turnpike - I-81, a Carlisle, PA hotel, is located just minutes form Historic Downtown Carlisle. Other local Carlisle attractions include the U.S. Army War College, Carlisle Car Show, Carlisle Barracks, Dickinson College, U.S. Army Heritage and Education Center, and a portion of the LeTort spring Run, a nationally-protected tributary of Conoduguinet Creek known for its natural fresh water trout fishing. Guests of our pet-friendly Carlisle hotel can enjoy amenities such as free hot breakfast, free WiFi, indoor heated pool, fitness center, business center and meeting rooms. All rooms feature hair dryers, microwaves, refrigerators and coffee makers. Book your room at the Comfort Inn PA Turnpike - I-81 in Carlisle, PA today!