Book now at the Comfort Inn hotel in Perryville, MO, conveniently located off Interstate 55 near Lake Perry, St. Joseph of Apple Creek, and Show Me Center. Amenities include free WiFi, free hot breakfast, an outdoor pool, and a fitness center. All guest rooms feature microwaves, refrigerators, and flat-panel TVs. Select rooms include work desks and hot tubs. Whether traveling to Perryville, MO for business or leisure, the Comfort Inn has everything you need. Book today!