Sleep Inn & Suites hotel in Hannibal, MO is located off Interstate 72, a short drive from Hannibal Regional Airport and Hannibal Regional Hospitals and Clinics. Mark Twain’s Boyhood Home, Becky Thatcher House, Norwoods Golf Club, Mark Twain Riverboat, Hannibal LaGrange University are also a short drive away from this pet-friendly hotel. Free amenities include hot breakfast, WiFi, coffee, parking and fitness center. Each room includes coffee makers, microwaves, refrigerators, hair dryers, 39-inch flat-screen TVs, irons and boards. Whether traveling for business, vacationing with the family or just passing through, the Sleep Inn hotel offers you ideal accommodations and affordable rates in Hannibal, MO. Make a reservation with us today!