Comfort Inn & Suites, a 100% smoke-free Chillicothe, MO hotel is located off U.S. Highway 35 near Poosey State Forest, General John J. Pershing Boyhood Home State Historic Site, the Locust Creek Covered Bridge State Historic Site, the J.C. Penney Museum, and Crowder State Park. Enjoy free WiFi, an indoor heated pool, hot tub, fitness center, laundry facilities, a business center and meeting space. Your Morning Breakfast is full of hot and delicious options, making breakfast at the Comfort Inn & Suites the perfect way to start your day. Enjoy our free hot breakfast featuring eggs, meat, yogurt, fresh fruit, cereal and more, including your choice of hot waffle flavors! Guest rooms offer microwaves, refrigerators, coffee makers, 32-inch flat-screen televisions, desks, hair dryers, irons, ironing boards and cable television. Book now!