Stay near the banks of the Ohio and Mississippi rivers at the Quality Inn Cairo I-57 hotel in Cairo, Illinois. Our location off Interstate 57 provides convenient access to Fort Defiance State Park, Wickliffe Mounds State Park, Magnolia Manor, Birds Blue Hole and Cypress Creek National Wildlife Refuge. Explore Cairo’s historic district, where you’ll find the Old Custom House, a former post office and courthouse that now serves as a museum. At the Quality Inn hotel, you’ll appreciate features and amenities that include free wi-fi, a free hot breakfast, free local calls, a seasonal outdoor pool and copy and fax services. Enjoy our outdoor picnic area and relax in guest rooms that are pet-friendly and include microwaves, refrigerators, hair dryers and cable television with HBO. During your travels to the Cairo, Illinois area, enjoy cozy and affordable accommodations at the Quality Inn Cairo I-57 hotel. Our staff looks forward to serving you.